Stories

cleveland clinic innovations launched spinoff company to create breast cancer vaccine
Cleveland Clinic Innovations has launched a spinoff company, Shield Biotech, out of the Lerner Research Institute. Led by Vincent Tuohy, the company is developing a vaccine for breast cancer.

The vaccine uses the body’s own immune system to fight off and kill cancerous tumors. Tuohy, who serves as Shield’s chief science officer, has been working on this theory for the past 11 years. 
 
The next step is to secure FDA approval for human clinical trials, probably within the next two years. Researchers found that a single vaccination could prevent breast tumors from occurring in mice genetically bred to develop breast cancer, while also inhibiting the growth of already existing breast tumors. The research was originally published in Nature Medicine in 2010.
 
“It works in animals,” says Tuohy. “It’s safe and very effective. We’d like to see women live longer without tumors, not women live longer with tumors.”
 
Tuohy sees the vaccine as particularly effective in breast cancers that are aggressive and tend to recur. “Triple-negative breast cancer has a higher recurrence rate than other forms of breast cancer and is insensitive to current forms of adjuvant therapy,” he says. “It’s the predominant form of breast cancer that occurs, for example, in women with BRCA1 mutations. “
 
Tuohy sees potential in eventually immunizing against prostrate and ovarian cancers as well. 

Source: Vincent Tuohy
Writer: Karin Connelly
business traveler covers westin hotel and land studio's local art program
Business Traveler covers the Westin Cleveland Downtown innovative program to bring local art into the soon-to-open hotel. The hotel is partnering up with LAND studio, a local nonprofit, to select area artists.

"Artwork from established and emerging Cleveland artists will adorn the hotel’s 484 guestrooms, lobby and public spaces. The program’s main event will be a signature large scale artwork from local artist Sarah Kabot in the lobby. The piece is slated for a February 2014 installation."

LANDStudio is working with Sage Hospitality, which owns the Westin Cleveland Downtown.

Read the rest here.
bowling with strangers: emerging patterns of desegregation foretell a vibrant economy
Cleveland, like most American cities, has had its challenges regarding segregation. But emerging patterns of desegregation can significantly advance our city's position as a center of innovation. This represents a key opportunity to reconstitute a new American neighborhood model by harnessing the potential of diversification.
rta healthline praised for cost/benefit ratio in forbes
In a Forbes feature titled “Bus Rapid Transit Spurs Development Better Than Light Rail or Streetcars: Study,” contributor Jeff McMahon writes of an upcoming report by the Institute for Transportation and Development Policy that explores the cost/benefit ratio of various types of urban transportation.
 
“For example, Cleveland’s Healthline, a BRT project completed on Cleveland’s Euclid Avenue in 2008, has generated $5.8 billion in development -- $114 for each transit dollar invested. Portland’s Blue Line, a light rail project completed in 1986, generated $3.74 per dollar invested.”
 
The report goes on to discuss the many variables going into the study and its relation to the urban environment.
 
Read the full piece here.

jumpstart's mentoring program gives young companies insight, business advice
JumpStart’s Burton D. Morgan Foundation Mentoring Program offers young companies a little additional insight into running a successful business. Each participating startup is assigned between one and four mentors.

“It really depends on the stage the company is at and what their needs are,” says Anthony Hughes, director of the program. “No one mentor is going to have all the skill sets needed as these companies take their ideas to fruition.”
 
Companies do have to be involved with JumpStart to enroll. Currently, 38 mentors are involved in the program and they have assisted 33 companies since it was launched in March of 2012. The program currently has 21 companies active.
 
“The companies have generated or raised $2.9 million in capital," says Hughes. "Startups with access to mentors and advisers are seven times more likely to raise capita and three and a half times as likely to gain customers. We are responsible for creating serial entrepreneurs and polishing the diamonds in this ecosystem. They’re really flying blind without access to people who have been there, done that.”
 
The mentors come from virtually every industry and background -- from Fortune 500 companies to venture capitalists, to leaders of nationally-know startups. “We’ll entertain anyone, but through a stringent evaluation process. We use mentors who are experienced and knowledgeable,” says Hughes. “Mentors are invitation-only. We’re not trying to be elitists or exclusive.”

 
Source: Anthony Hughes
Writer: Karin Connelly
modern-day home ec school agrarian collective teaches the 'hows of the home'
Kelli Hanley Potts has lived in Denver and Albuquerque, where she got involved in the slow food movement, replaced her front lawn with a vegetable garden, and worked for some of those cities' top chefs. When she got the urge to move back home to Cleveland, she knew she wanted to do something food-related.

That's when she stumbled upon a business idea. Despite the rise of the local food movement, most people had no idea how to cook kale, make jam or preserve food. She asked 18 female friends if they knew how to make a pie from scratch, and only two said yes.

Additionally, many people in the local farming movement have trouble explaining and marketing their products to customers, who are largely unfamiliar with them, she explains.

There are no cooking schools in Cleveland that did what she wanted to do -- connect people back to the land and back to their grandmothers' kitchens by teaching them the age-old skills of home economics -- so she decided to create one.

"I didn't want to watch a chef in front of me and drink wine," says Hanley Potts. "I wanted to learn something. I wanted to reconnect people to the lineage of the table, help them build their own table culture."

She recently launched the Agrarian Collective, an earth-to-table lifestyle school. Her mobile cooking school is offering classes this fall that cover topics like roasting your own coffee, fermented and cultured foods, and discovering local apples, among others. She'll be teaching students how to make the perfect pesto at this weekend's Cleveland Flea.

She was aided by a $5,000 low-interest loan from Bad Girl Ventures, which enabled her to purchase supplies and begin reaching out to chefs and farmers as partners.

"This is like home ec, but not quite as official and nerdy," she says. "It's about reconnecting people. All these things we once learned and were taught, they're missing. We're teaching people the 'how' of home."

Source: Kelli Hanley Potts
Writer: Lee Chilcote
downtown cleveland alliance hosts first all-ohio BID conference
As millenials, empty nesters and other demographic groups flock to downtowns across Ohio, business improvement districts -- or BIDs -- are playing an important role in ensuring that these areas are clean and safe and that residents, office workers and property owners have the amenities they need to thrive.

A business improvement district is a defined area in which property owners pay an additional tax in order to fund projects and services that enhance the area. Downtown Cleveland has a BID, and the organization provides basic "clean and safe" services, organizes events and markets downtown to prospective residents, visitors and businesses.

This week, Downtown Cleveland Alliance, which manages the downtown BID, organized the first all-Ohio BID conference, bringing together BID leaders from across the state to network and learn about issues they share in common.

"It came from the idea that there's not a unifying organization or conference for BIDs," says Anna Beyerle with DCA. "We can learn a lot from other BIDs across Ohio. The idea was to get in the same room and throw out ideas and best practices."

Topics included food truck legislation, downtown transportation, farmers markets, placemaking, and office and retail recruitment strategies.

Participants also enjoyed several tours of downtown Cleveland and the surrounding area and had a chance to learn from Cleveland's redevelopment.

Beyerle says the conference will help BIDs, such as the one in downtown Cleveland, to become more effective. "We're up for renewal in a couple years, and we're looking at how we can improve."


Source: Anna Beyerle
Writer: Lee Chilcote
as acendex looks to fill senior tech positions, it trains entry-level staffers
Since 1988, Beachwood-based Acendex has been the go-to IT consulting company for businesses looking for information and communications systems. “We’re like the IT department for companies too small to afford the talent and too large to not have high-end support for their systems,” says Jonathan Husni, founder and president of Acendex.
 
The Acendex philosophy is to let their clients focus on what they do, while Husni and his team build the right voice and data networks to help them do those jobs.
 
With the local economy improving, business has picked up. To cover the increased business, Acendex is looking to add three or four senior network engineers to its 14-person team. But Husni is having trouble finding talented people to keep up with client demands.
 
“Just finding folks who have the skill set I’m looking for is very, very difficult,” he says. “The guys who have been with me who are successful have been with me 10 to 15 years.” Like many IT companies, Husni finds that applicants have the training, but they don’t have the hands-on experience. “A lot of people have the credentials, but they don’t have the experience to back it up,” he says.
 
So in the meantime, Husni came up with a solution. He hires entry-level people and puts them in the field with clients who want someone on-site 40 hours a week. They have the knowledge for basic support and at the same time have the backup of senior level staff if there’s a more advanced problem.
 
“They get the opportunity to get real world experience, but when they get stuck they can call our senior engineers.” Husni says. “It’s a sort of proving ground. It works for the client because they get 40 hours of help at a low cost. It works for me because they get the training they need.”
 
 
Source: Jonathan Husni
Writer: Karin Connelly
halfway there: sustainable cleveland environmental initiative making progress, says city official
Are you sustainable, Cleveland? That's the question environmentally conscious city officials are asking heading into the fifth annual Sustainable Cleveland 2019 Summit. The initiative to build "a green city on a blue lake" is at the halfway mark, and Cleveland's new chief of sustainability believes Northeast Ohio is meeting the metrics set out a half decade ago.
symon empire expanding into metro detroit
In a Detroit Free Press story titled “Michael Symon’s B Spot Burgers coming to Rochester Hills in December,” restaurant critic Sylvia Rector writes of celebrity chef and Cleveland native Michael Symon’s decision to expand his culinary presence in the Detroit metropolitan area, where he already owns a restaurant, Roast, in the Detroit Westin Book Cadillac hotel.
 
“We are off and running, and we are very excited to be there,” Doug Petkovic, co-owner of the company with Michael and Liz Symon, was quoted as saying.
 
The company signed a lease in August and has been touring some of developer Dan Gilbert’s downtown Detroit buildings.
 
“We are a down and dirty burger joint,” Petkovic added. “Our concept is meat on meat. We do some interesting combinations. We’ll take our beef and top it with bologna or pastrami, or corned beef at times. We do some with pulled pork.”
 
Check out the full story here.
travel writer swoons over cleveland visit
In a Huffington Post travel feature titled "The American Grandeur of Cleveland," contributor Sally Fay was so smitten by our city that she writes, "There are many reasons to visit Cleveland, enough to swing the vote right into moving there!"
 
She writes that "Cleveland has a character that appreciates its past while embracing the renewal of the future. In 2013, the city has a different kind of American grandeur than it did in its industrial heyday of the early 20th century, but rather than get stuck in the past and not learn the lessons from it, Cleveland has aged well into a modern, global and down-to-earth city."
 
Stops on her exhaustive visit through town included Lake View Cemetery, Cleveland Cultural Gardens, Cleveland Art Museum, Severance Hall, Museum of Contemporary Art, Cleveland Institute of Music, Rock and Roll Hall of Fame, PlayhouseSquare, West Side Market and many other stops.
 
She closes out the piece with this resounding endorsement:
 
"If you are looking for opportunities, reasonably priced real estate, cultural diversity, high culture, top medicine, professional sports and mid-western charm, pack your bags and discover the American grandeur and quality of life of Cleveland has going for it!"
 
Read the rest right here.

insivia broadens its services, expands its staff
When Andy Halko founded Insivia right out of college in 2002, he was more of a freelancer, picking up projects piece by piece. Today, the company is a full-service marketing firm working out of the Agora in Midtown.
 
“We’ve really evolved into a strategic marketing firm for our clients,” says Rick Scheeser, Insivia's director of operations. “Nowadays we’re their entire marketing department. We have a more strategic partnership with our clients, and we have a lot more control over what we do.”
 
Over the past year Insivia has developed its client base, grown into a 16-person company, and is looking to add a back-end developer and an account executive.
 
“Before we had lots of one-off projects,” says Scheeser. “Now our clients are more our partners; we’re working with them on a long-term basis.”
 
Scheeser says Insivia has developed a niche market in the manufacturing industry. “It really helps us understand how we can use technology in their businesses and communicate with their clients,” he says regarding developing an expertise in the market. “I don’t think you could be in Cleveland without helping manufacturing companies.”
 
Another niche evolves around small tech startups. But Scheeser says no matter what the industry, Insivia gets to know the inner workings of the client. "It’s all about learning about our clients,” he says. “We focus on long-term objectives from a marketing perspective. It allows us to really own the results, instead of just one small piece.”
 
Source: Rick Scheeser
Writer: Karin Connelly

renovated shoreway building will offer 45 loft apartments with stunning lake, city views
There are very few properties in Cleveland where a resident can don a pair sandals and stroll straight to the beach from one's front door. But when it comes online next summer, the Shoreway Building will join that small and privileged group.

The building at 1260 W. 76th Street, once home to the Globe Machine and Stamping Company, has been used for years as a storage facility by the Catan family (of Pat Catan's Craft Centers).

With the reopening of the pedestrian tunnel at W. 76th Street -- a few feet from the building -- the Catans recognized that it was time to reenergize the building as a hub for city living.

Using a combination of state and federal historic tax credits and other financing sources, the Catans are renovating the empty building into 45 market-rate loft apartments with indoor and outdoor parking, huge windows and a common roof deck boasting matchless lake and downtown views.

The building also will feature an indoor fitness center and a small street-level retail space that could become home to a future cafe.

"These are true loft-style units," says Michael Augoustidis, an architect with Domokur Architects who helped design the project. "They have exposed brick walls, really big industrial-style windows, exposed concrete ceilings and concrete floors."

Augoustidis says the level of quality will set the building apart. All units will have gourmet kitchens featuring Corian countertops, hardwood cabinets, and boast an "urban feel."

There isn't a bad view in the building. The structure's orientation allows for stunning treetop views looking out over Edgewater Park and Lake Erie, or dramatic urban views looking out over the lake, Battery Park and downtown. You choose.

Units will be between 900 and 1,400 square feet and will lease for $1,000-1,900 per month.
 
Augoustidis says that units will be ready starting in May or June of next year, and that some of the old wood plank floors will be upcycled into common area design elements.


Source: Michael Augoustidis
Writer: Lee Chilcote
summer festival slideshow
As summer transitions into fall, we wanted to take a moment to look back on a season filled with family, friends and festive neighborhood gatherings. Throughout it all, Fresh Water photographer Bob Perkoski has been attending and shooting the best summer festivals. This slideshow features captured images from a dozen events.
clinic's cosgrove aims to improve health of residents and city
In a lengthy Forbes feature titled "City Surgeon: Can The Cleveland Clinic Save Its Hometown?" writer Matthew Herper reports on Delos “Toby” Cosgrove's tenure at the Cleveland Clinic and his efforts to leverage healthcare to improve the Clinic's neighborhood and the region's economy.
 
"The rough old neighborhood is a distant memory, replaced by a gleaming testament to modern medicine stretching out over 46 buildings and covering 167 acres. Protected by a dedicated 141-trooper force of state police, there is a conference center, a fancy hotel and a farmers’ market. Over Cosgrove’s tenure the clinic’s revenues have nearly doubled to $6.2 billion."
 
But Cosgrove's biggest brainstorm was to build a "giant mall for hospital buyers." 
 
"Think about the things that go into a hospital. Shades, televisions, chairs, tables, wall coverings, all the medical gear, the operating tables, you name it,” Cosgrove is quoted in the piece.
 
"What is emerging is an Epcot Center for med tech. GE Healthcare, Siemens, Philips Health Care and Cardinal Health are among the 22 confirmed tenants in the soon-to-be-completed center. Next door, Bennett has already booked conventions that will bring 89,395 attendees this year and 100,400 next. By the end of 2016, he says, bookings should be enough to pay back the $465 million it took to construct both buildings."
 
“It will begin to influence the city as it comes back and make it a destination medical city,” Cosgrove predicts.
 
Read the rest of the article here.

nine northeast ohio biomed companies named to inc. 5000
Nine local biomedical companies were named to this year’s Inc. 5000 list, a tally of the fastest growing companies in the country in terms of jobs and revenue. Inc. measured revenue growth from 2009 to 2012.
 
The list represents companies across every industry, but the number of area biomed companies named to the list is encouraging to the growing biomed industry in Cleveland.
 
“It’s a very exciting time right now in Northeast Ohio for the biomedical industry," says Aram Nerpouni, president and CEO of BioEnterprise. “It’s a little bit of validation here that you can really grow and thrive in the region.”
 
Nerpouni says the list reflects a combination of young startups and more established companies. Cleveland-based Bravo Wellness, founded in 2008, ranked 888 overall on the Inc. 5000 list. The company, which provides health insurance consulting, ranked 68 on the top 100 health companies. Bravo added 94 jobs in the past three years.
 
Twinsburg-based CoverMyMeds ranked at the top of the Ohio healthcare companies at 96 on the Inc. 5000 list. The company added 32 employees in the past three years.
 
“You’re beginning to see a lot of young companies looking at the area,” says Nerpouni of the Health Tech Corridor, located between University Circle and the Campus District. “We should start seeing more and more activity.” Already, 500,000 square feet have opened up in the area in the last six months, with 80 percent occupancy.
 
In 2012, 43 Cleveland biomedical companies raised $227 million in equity funding.

 
Source: Aram Nerpouni
Writer: Karin Connelly
cleveland among top metros for college grads
In a The Atlantic report titled “The Best U.S. Metros for Recent College Grads Looking For Work,” writer Richard Florida shares a lengthy report on which areas in the United States offer the best opportunities for the newly minted young and educated looking to start life in the “real world.”
 
While the standard San Francisco, Boston, Seattle, and Austin metros continue to receive high marks, others such as New York City, Chicago, and Los Angeles leave much to be desired for they younger generation.
 
Cleveland may not have broken the Top 10 just yet, but it does place in the Top 20, and is on the move.
 
“The good news is that Rust Belt metros like Detroit, Pittsburgh and Cleveland appear to have turned the corner. These metros have a lot to offer highly educated recent grads: affordable housing, a low cost of living, authentic neighborhoods, and revitalizing cores, as well as a relatively high level of job openings for in fast-growing highly-educated fields.”
 
Enjoy the complete report here.

the atlantic praises new online rust-centric magazine
In The Atlantic, a story titled “A New Magazine Takes on Old Rust Belt Stereotypes” and written by Bonnie Tsui shares information on a new Cleveland-focused “Rust Belt Chic” online magazine titled Belt.
 
"Rust Belt Chic is a movement," the piece begins. "That’s according to a new online magazine out of Cleveland, Belt, that aims to address the highly specific and often superficial attention paid to a wide swath of deindustrialized America."
 
In a meaty interview, editor Anne Trubek says the publication will focus on what they can do consistently well: intensely and well-edited long-form journalism, commentary, and first-person essays.
 
“Our first issue is queued up and ready to go, and it’s fantastic," she explains. "We have a deep dive on the Anisfield-Wolf Awards, a 78-year-old Cleveland-based book award for works that address issues of racism, which has an incredibly high caliber of past and present awardees and famous jurors but an oddly low profile in town and the nation. And we have a hilarious essay, 'S&M in the CLE' by novelist Alissa Nutting, whose book Tampa has been the talk of the literary world this summer.”
 
Check out the full piece here.


career by design: cia grad fills his days with art, design, music and magic
Jason Tilk, a Cleveland Institute of Art graduate, designs award-winning medical innovations for Nottingham Spirk, the Cleveland-based business innovation firm. By night, the wildly creative trailblazer performs Vaudeville-style shows with his wife that incorporate songs, jokes and "bad magic."
case nabs number four spot on prestigious college rankings list
In the 2013 edition of its annual National Universities Rankings, Washington Monthly awarded the number four spot to Case Western Reserve University. In fact, with an overall school of 93, Case shares the number three spot with Texas A&M.

The ratings are unique in that they rank schools not on various academic statistics but rather on their contribution to the public good.  Specifically, they look at three broad categories: Social Mobility (recruiting and graduating low-income students), Research (producing cutting-edge scholarship and PhDs), and Service (encouraging students to give something back to their country).

Check out the complete rankings here.