Thermalin Diabetes, a JumpStart Ventures portfolio company, recently closed $2.85 million in Series A investments, paving the way to the further development of short, medium and long lasting insulin analogs by Case Western Reserve Medical School Dr. Michael A. Weiss.

The announcement includes a second $250,000 investment from JumpStart, and exceeds Thermalin's original target by $1 million. "Having this round closed is great," says Thermalin CEO Rick Berenson. "I'm very excited about the progress. I'm looking forward to being able to report further progress."

The company is now moving immediately into Series B, in which the hope is to raise another $8 million. "With that we should be able to get through [the first] phases of studies."

The patents on existing insulins on the market are due to expire in 2013 and 2014, so the interest in Thermalin's developments is huge worldwide. Weiss' work centers around developing insulins that are more stable and effective on a more timely basis.

Thermalin has developed about 40 different analogs. The funding will allow the company to continue testing to determine which analogs to commercialize.

Insulin is a $14 billion a year market -- the largest volume drug market in the world. Insulin sales are expected to double in the U.S., triple in Europe and increase 12-fold elsewhere in the world as the disease reaches epidemic levels.

Thermalin employs six full time scientists at the Cleveland Clinic's Global Cardiovascular Innovation Center. The investment allows for additional key hires, including a senior scientist.


Source: Rick Berenson
Writer: Karin Connelly

April and May bring out the best in design during the inaugural Cleveland Design Month-and-a-Half, which features two events that show off the talents of local design students as well as regional and national designers.

The Cleveland Institute of Art's annual Spring Design Show, a tradition for more than 20 years, kicks off on Tuesday, April 19, while the Cleveland Furniture Fair, hosted by Cleveland's District of Design, begins May 16.

In the spring show student work in industrial, interior and communication design will be on display for the public, as well as national employers in Case Western Reserve's Peter B. Lewis building. "More than 100 students show work and interview for internships," says CIA's head of industrial design, Dan Cuffaro. "It's a big job fair." A free public reception from 5:30 p.m. to 8 p.m. will kick off the event.

Throughout the week, designers hailing from some of the most progressive firms in the world will present a series of free lectures to the public.

The second annual Cleveland Furniture Fair will show off the brightest designers and manufacturers of furniture, lighting, millwork and more. This year's fair has a greater variety of designers from Northeast Ohio, unique seminars tailored specifically for exhibitors and the public, as well as pop-up retail shops and a variety of design-focused events.

Additionally, the American Institute of Architects (AIA) Cleveland Chapter has a calendar full of lectures, exhibitions, and tours open to the public that will introduce new and exciting architecture and design to Northeast Ohio.


Sources: Dan Cuffaro, Casey Burry
Writer: Karin Connelly

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If Walter Wirth has his way, every restaurant in Cleveland will soon offer wine on tap. Yes, you read that right -- wine served from a keg. In fact, there is no good reason not to. In addition to providing the freshest possible product at the lowest possible price, the wine-by-the keg approach is as eco-friendly as it gets. While the concept may be new to Ohio, it is by no means a new concept.

Although jewelry maker Heather Moore moved into her rehabbed Midtown studio earlier this year, she's still getting used to her spacious new digs.

Maybe that's because she's spent the last 11 years running her fast-growing business out of her house. Granted, it was no ordinary home office: the Cleveland Institute of Art grad bought her great-grandmother's estate, a rambling Heights mansion, after moving back from New York City in 1999.

"We just couldn't grow anymore -- I had 45 employees working out of my house," says Moore, whose company, Heather B. Moore Jewelry, specializes in custom-made, personalized jewelry that she sells to more than 150 retailers around the world. "The workshop was in the basement, while sales and marketing were in the attic. If we needed to have a private conversation, we had to use one of my kids' bedrooms."

To accommodate her growth, Moore recently bought and renovated a former crane-making factory at 4502 Prospect Avenue, bringing 45 new jobs to Cleveland. In her renovation, Moore reused as much of the building as she could, including leftover crane parts that were repurposed into a dining room table that now graces the large kitchen.

Moore's building renovation included removing ceilings to create a lofted second-floor office, installing new windows, and turning an old garage door into a light-filled window. Future plans include an art gallery, new patio and roof garden.

When asked about her decision to relocate to Midtown, Moore says, "There's so much industry in Cleveland that you can take advantage of. A lot of what we do mixes old school techniques with newer technologies, so this is a great place to be."

Heather B. Moore Jewelry has become known not only for its work -- Moore builds relationships with her clients to draw out their stories and create highly personalized jewelry -- but also for its sustainable business model. The company uses 100-percent recycled materials in their products.

Now that she's settled into her new studio, Moore is soaking up the extra legroom -- and she also doesn't mind the short commute. "It's seven minutes from my house," she says.


Source: Heather Moore
Writer: Lee Chilcote

Inside the ultra-sleek Vitrolite Glass building overlooking the Shoreway, the Intermuseum Conservation Association is an oft overlooked jewel of the fine-arts world. Inside its walls is a trove of timeless treasures, with precious relics from Coney Island to Ancient Rome and even Cleveland receiving matchless care, attention and preservation before returning to the walls of museums, galleries and private collectors.

American Greetings has made it possible to send a loved one a greeting card with birthday candles to blow out -- literally. The new line of cards called Ready, Set, Blow features six scenarios in which recipients are prompted to blow on the card. The puff of air prompts the card to come to life with LED lights, a song and sounds.

Users blow on the cards to extinguish birthday candles, toot a horn, or make a wish on a dandelion. The cards are designed to please recipients of all ages, and they can be used again and again.

"Ready, Set, Blow lets people experience the birthday tradition of wishing in an innovative new way," says Carol Miller, executive director of new product concepts at American Greetings. "It's so much fun to see someone receive these cards because you get to watch their surprise as they open it and then their smile unfold as the card comes to life -- and hopefully, their wish granted."

The result is an interactive experience that is the next-best thing to actually being there. American Greetings launched the line in March at retailers nationwide. They sell for $6.99 each.


Source: Carol Miller
Writer: Karin Connelly

Rather than make a beeline for warmer climes, environmental advocate Philippe Cousteau will leave the chilly Arctic Circle (current temps: brutal) and head straight to Cleveland. The handsome grandson of Captain Jacques Cousteau, and environmental correspondent for CNN, will be in town to headline the third annual Green Gala. To be held Friday, April 8 at Executive Caterers, the event is the principal fundraiser for EcoWatch, an Ohio-based nonprofit that provides a voice for environmental organizations. The organization's bimonthly newspaper EcoWatch Journal is available free at over 2000 locations statewide.

A large map on the wall of Crafty Goodness, a new Lakewood store that sells goods from artisans that live in Northeast Ohio, provides a visual reminder of the store's mission. It pinpoints all of the different communities where the items are made, stressing the owners' commitment to the buy local movement.

"We wanted to create a store that would offer an alternative to big box retail for people that want to buy local," says Chris Sorenson, a potter who joined with artists Joanna and Matthew Orgovan to open the store at 15621 Madison Avenue.

Crafty Goodness got its start as a modern arts and crafts show that was held in Seven Hills in 2009. The success of that show inspired its creators to set up a bricks and mortar store, and a year and a half later, Crafty Goodness was born. The store, which opened in March, will celebrate its grand opening on Saturday, April 9th.

In addition to items such as clothing, home décor, jewelry, book bags, cards and notebooks, Crafty Goodness features an extensive art gallery on the walls, with more than 60 artists from seven Northeast Ohio counties represented. The owners selected Lakewood because of the community's commitment to the arts and small, local businesses.

Despite being only 750 square feet, Crafty Goodness offers a wide array of merchandise. Sorenson plans to continue hosting the annual craft show and hopes to find a space in Lakewood for this year's event.

Crafty Goodness also hosts a variety of classes, including jewelry making, needle arts and vegan baking, for consumers of all ages. The majority of the classes, which run about two hours and are affordably priced in the $20-35 range, are presented in a make-and-take format, which lets participants go home with an original work of art.

Source: Chris Sorenson
Writer: Lee Chilcote

Imagine this: A $10,000 solar-energy system powering an entire elementary school in Africa, providing enough juice for laptop computers and overhead lights. Christopher Clark, founder of Sunflower Solutions, has proved that this feat is not only possible, but also is an efficient, cost-effective way to bring power to the Third World.

Recently, Sunflower Solutions moved to Shaker LaunchHouse, a former auto dealership turned business incubator in Shaker Heights. Created with just $60,000 in seed funding, the company is in its first year of producing manually trackable solar power systems. These systems allow users to move panels by hand as the sun moves across the sky, obtaining up to 42 percent more power.

Sunflower has sold its systems to nonprofit organizations in six countries, including India, Kenya and Nigeria, and Clark says the company will achieve profitability this year.

Clark first developed the idea when he was a business major at Miami University of Ohio. "I was helping some engineers develop a water pump for a village without electricity in Mali," he says. "They installed it, and then realized that the water was too deep underground for a hand pump. If they'd used an electric pump, it could have worked, yet there was no electricity for miles around."

The solution was solar power. Yet while trackable solar systems have been around for decades, most of them move automatically and are expensive. Clark's invention is the first manual system. "It's hard to do anything about poverty, health care and education in the Third World without basic electricity, yet two billion people in the world don't have it," says Clark. "This system allows nonprofits and charities to purchase a better, lower-cost system."

Sunflower Solutions' products are made locally by South Shore Controls in Cleveland and Perry, Ohio. As his business grows, Clark hopes to market his products to a wider audience, allowing his system to reach even more people in the developing world.

This summer, Clevelanders will be able to see the power of Clark's invention firsthand. The Cleveland Museum of Natural History is installing a system on its campus; the Metroparks Zoo is also interested.

Clark was selected as one of the speakers for the April 15th TEDxCLE conference, where he will talk about "electricity as a basic right."


Source: Christopher Clark
Writer: Lee Chilcote

The Rag Refinery, a new store that offers gently used, recycled fashions at affordable prices, just opened at 3904 Lorain Avenue in Ohio City. Owner Leigh Ring also manages Pink Eye Gallery in the same space, where she often rolls out the racks to host art openings.

"Our focus is on vintage shoes, clothing and accessories, and we invite customers to sell or trade-in their former favorites for cash or store credit," says Ring. "Our customers want to outfit themselves in creative and unique ways."

Ring chose Lorain Ave. because of the proliferation of affordable vacant spaces and because Ohio City is a draw for her customers. "With the help of Palookaville Chili next door and places like Open Yoga Gallery, we hope to be a part of the revitalization that's happening here," says Ring.

The Rag Refinery is currently open on Saturdays from noon to 5 p.m. and by appointment. However, Ring plans to extend her hours to match those of Palookaville Chili's April 20th opening. "There will be an open hallway between the Rag Refinery and Palookaville so that customers can both browse the shop and have a bite to eat," explains Ring.

Ring is energized by the small-scale redevelopment trend she sees on Lorain. "There is already a draw for antiques and vintage here, but my hope is that more restaurants and shops choose Lorain, joining together to make the street more walkable."

She also sees her store's mission of recycled fashions contributing to the sustainability movement. "By recycling and reusing clothing and keeping it out of our landfills, we're doing our part," says Ring.


Source: Leigh Ring
Writer: Lee Chilcote

When it comes to sustainability, we are all lifelong students. Cleveland's higher education institutions are not excluded from this learning process. In fact, area colleges and universities spent a year reflecting upon on-campus sustainability initiatives and ways to improve current practices.

The Collegiate Sustainable Practices Consortium (CSPC) brought together six local colleges and universities to talk about best practices regarding energy, water, food, building and other areas of sustainability. Led by David Kruger, director of Baldwin-Wallace's Institute for Sustainable Business Practice (ISBP), the group included B-W, Case Western Reserve University, Cleveland State University, Cuyahoga Community College, John Carroll and Oberlin.

Kruger noted in a summary of the consortium that "with its highly industrialized, manufacturing base, [our region] carries a long legacy of sustainability-related challenges: slowly declining employment in several economic sectors; a large environmental and carbon footprint from our manufacturing base; continued population decline in our urban core and in our region at large; and an aging infrastructure."

A recently released report shows what some local higher learning institutions have implemented regarding sustainability:

Baldwin Wallace's Ernthausen Residence Hall became the first residence hall in Ohio to have a geothermal heating and cooling system. . B-W has gone so far in its green initiatives to remove light bulbs from vending machine to conserve energy.

Cleveland State University has been investing in efficient lighting, solar power, mechanical upgrades and recycling programs. The school has been promoting student involvement in its sustainability efforts.

Cuyahoga Community College has six commissioned projects aiming aim for LEED Silver Certification. Tri-C has also developed its own customized green building standards for new construction and renovation projects.


SOURCES: B-W, CSU, Tri-C, Institute for Sustainable Business Practice
WRITER: Diane DiPiero

TEDxCLE is an annual forum that gathers the region's big thinkers to share ideas worth spreading. Organizers -- and recent "brain gains" -- Hallie Bram and Eric Kogelschatz seek to change the perceptions of people who live here as well as those outside the region by sharing stories of success, innovation and inspiration.

"Urban agriculture" is no longer an oxymoron in Cleveland. The city is a nationwide leader in urban farming, boasting one of the largest urban farms in America. There's more to local food than flavor. By shifting one quarter of Northeast Ohio's food-buying needs from out-of-state sources to local food producers we can pour $4.2 billion into the regional economy.

The picturesque Doan Brook meanders through Cleveland Heights and Shaker Heights, providing walkers and joggers with a scenic backdrop. Yet the section that flows through Cleveland's Rockefeller Park remains boxed in by crumbling stone walls.

This year, a $2.5 million project to restore these portions of the Doan Brook will finally get started. The project will remove failing stone walls and concrete dams for nearly a half-mile, allowing the stream to flow more naturally while improving water quality and increasing fish populations.

"This project could serve as a model for other communities that are seeking to create healthier streams in urban areas," says Victoria Mills, Executive Director of the nonprofit Doan Brook Watershed Partnership.

The Doan Brook project was originally slated to receive $5.5 million, but was scaled back after bids came in over budget. The new plan addresses these concerns by creating natural terraces that improve drainage and reduce flooding without threatening portions of the gardens. The Northeast Ohio Regional Sewer District (NEORSD) will manage the design and construction process.

Although the project is smaller in scale than originally envisioned, Mills is excited about its impact. "I am hopeful that it will spur more improvement projects in Rockefeller Park, including a new master plan," she says.

The Doan Brook improvement project was conceived in 2001, when the Ohio Environmental Protection Agency (EPA) ordered the city to restore the brook to compensate for the loss of 88 acres of wetland and more than a mile of Abram Creek at Cleveland Hopkins International Airport. Abram Creek was destroyed to allow for a new runway to be built. The EPA required the city to complete $15 million in restoration projects, most of which have now been completed.

The brook is rare among Cleveland's urban streams because much of it remains above ground. The Doan Brook Watershed Partnership was formed in 2001 to coordinate the preservation efforts of the cities of Cleveland Heights, Shaker Heights, Cleveland and interested citizens. Over the years, Doan Brook has developed an active constituency dedicated to its renewal. The Doan Brook Watershed Partnership will hold a clean-up day on April 17th. To register call 216-321-5935 x 237 or visit the website.

The $2.5 million project will also remove some invasive species and allow limited access to the brook, but will not address flooding.


Source: Victoria Mills
Writer: Lee Chilcote