Cleveland-area SPR Therapeutics is tackling the chronic pain market with its Smartpatch technology. The Smartpatch external stimulator delivers an electrical signal to an electrode placed in the muscle. The electrical signals stimulate the target nerve within the muscle, thereby exercising the muscle to treat the pain. The Smartpatch system will serve the $150 billion pain market, in particular those suffering shoulder pain from strokes, as well as chronic lower back pain.

"It's a very simple short-term therapy that can eliminate chronic pain," says Maria Bennett, president and CEO of SPR. "It can be administered by a surgeon or non-surgeon, has no side effects and is completely reversible."

The company, which was founded in January 2010, is a spinoff of NDI Medical, which developed the technology and licensed it SPR. JumpStart Ventures announced last week that it will invest $250,000 in SPR Therapeutics to help bring the technology to market later this year or in early 2012.

"JumpStart's investment really allows us to complete the commercialization," says Bennett. "It helps us get to market, be prepared with all the pieces and parts so we can really hit the ground running."

Meant for use up to 30 days, Smartpatch has also demonstrated long-term pain relief. The company's series of clinical feasibility studies demonstrated that, at the end of the short-term therapy, 84 percent of patients experienced a significant reduction in pain and 40 percent were pain free. After completing the Smartpatch therapy, 78 percent of these patients continued to have significant pain relief.


Source: Maria Bennett
Writer: Karin Connelly

State Farm Insurance is looking for bi-lingual agents with an entrepreneurial spirit. So the agency is holding a job fair at Asian Town Center, located in Cleveland's Asiatown neighborhood, on May 17 from 5:30 p.m. to 7:30 p.m..

"State Farm has really got a push on the multi-cultural market," says Kevin Perry, senior State Farm field executive in the company's Beachwood office. "As a growing company we noticed we didn't have a lot of agents across diverse backgrounds."

Perry says Cleveland offers just the diversity State Farm is looking for. "We thought we'd go out and see what we can find and just go from there," he says. The company sponsored an event at Asia Town Center in January and "it went really well," so it seemed like the right location for a second one.

Ideally, State Farm would like to have an agent in Cleveland's Asiatown neighborhood. "With its location, we'd like to have an agent in there just to have a presence," Perry says. But the company is looking for agents who speak any language in addition to English.

"The right potential agent, with good credit, will be funded by State Farm for startup costs. Agents will receive an $18,000 signing bonus, an additional $12,000 after the first year, a $25,000 line of credit, and a credit card with a $5,000 limit.

"If you enjoy working with people, helping people, educating people, and you're interested in being an entrepreneur you should come in," says Perry. "We're looking for folks who want to be anchored in the community and looking to grow the market."


Source: Kevin Perry
Writer: Karen Connelly

MC2 STEM High School was named a regional runner-up in an energy conservation competition sponsored by Alcoa Foundation and the Pew Center on Global Climate Change in Arlington, VA. The competition, called Make an Impact: Change our 2morrow (CO2), awarded STEM High School a $1,000 grant for completing the most calculations on how to reduce the carbon footprint with a carbon calculator.

"It was an opportunity for students, teachers, parents and administrators to have hands-on experience in learning about energy conservation in the home," says Vivian Davis, communications and community relations manager for Alcoa in Cleveland.

Three schools in Cleveland participated in the challenge that involved 15 schools nationwide and more than 8,000 students. The Make an Impact: Change Our 2morrow challenge is part of a new $7 million Alcoa Foundation investment to address regional environmental challenges, improve energy efficiency and enhance global reforestation projects.

In addition to the carbon calculators, schools were given a range of educational materials to get students excited about the challenge. MC2 STEM High school, located in the Great Lakes Science Center and GE Lighting's Nela Park in East Cleveland, focuses on hands-on education in science, technology, engineering and math. "It was such a delight," Davis says of the challenge, "We were able to see the school's mission come to life -- to prepare students in stem sciences. I was so impressed."


Source: Vivian Davis
Writer: Karen Connelly

Cleveland is an entrepreneurial hotspot right now, and big business in Cleveland wants to make sure local women-owned outfits have equal footing. Springboard Enterprises has joined forces with Ohio-based powerhouses KeyBank, Thompson Hine, and Meaden & Moore to provide women with the keys to building big businesses.

Build it Big is a business development program for women-owned businesses on the fast track to growth. "It's about educating business owners on how to find equity investors and financing," says Maria Coyne, executive vice president of business banking for Key. "It's really about targeting for growth and the desire to grow rapidly."

Applications are being taken through May 23. The number of applicants accepted into the program depends on how many apply, but all applicants will get at least some input. To qualify, companies must have a woman in a key management position with a significant ownership stake; demonstrate a qualified and profitable market opportunity, a track record of milestone achievement and a credible core management team or an ability to attract one.

Companies selected to participate will meet one-on-one with the Build It Big partners to chart effective strategies for growing their businesses, including choosing the right capital, getting the fiscal house in order, and important legal issues such as product licensing, royalties and protecting the company's intellectual property.

The program can only mean good things for Cleveland's entrepreneurial spirit. "We think it's great for Cleveland because we like to grow our own," says Coyne. "We have an entrepreneurial history. Build it Big improves sustainability and growth for all our businesses. And we want to have a shared interest in their success."

Source: Maria Coyne
Writer: Karin Connelly

Lights, camera, action!

Paramount Pictures announced plans to shoot an untitled film this summer in Cleveland and surrounding areas. The movie, starring Nickelodeon's Victoria Justice, will be directed by Josh Schwartz and produced by Michael Beugg. It is one of three major motion pictures slated for production in Greater Cleveland this summer.

"I think it's going to be a very exciting summer," says Greater Cleveland Film Commission executive director Ivan Schwarz. "It's creating the infrastructure, jobs and economic development in the area." The film is expected to employ 545 people, including cast, crew and extras.

The Paramount movie is just one part of Schwarz's plan to create 2,500 film-related jobs in everything from driving trucks to catering. "I want to create an industry; I don't want a boutique," he says. "Young people in our state and our community have a choice to work in an industry that's cool and pays well."

The production has been approved to receive funding through the Ohio Motion Picture Tax Credit, administered by the Ohio Department of Development's Ohio Film Office.

Cleveland is becoming more and more attractive to filmmakers because of its diverse scenery. "There is nothing you can't film here except for mountains and desert," says Schwarz. Katie Sabatino, spokesperson for the Ohio Film Office, adds, "Cleveland has a fantastic cast and crew base. With the bigger city and the small towns, it will look like any city or town you need. That's been a really attractive selling point for the film industry."

Source: Ivan Schwarz
Writer: Karin Connelly

While it's common for individual companies to develop a business plan to help prepare for success, Northeast Ohio is one of only three regions in the country to pilot a regional business development plan. The Partnership for Regional Innovation Services to Manufacturers (PRISM) will be headed by MAGNET to help small and medium sized manufacturers thrive in the region.

"It's basically a way to ramp up the level of innovation in the manufacturing sector," says John Schober, MAGNET's director of innovation. "Lots of businesses out there have the potential to grow, but they don't have the resources available to grow."

For instance, these companies may not have access to resources such as marketing or R&D departments. "The PRISM program will help manufacturers identify and access these resourcces," says Schober. "People have been talking about what's going wrong for a while, but no one's talking about what to do about it."

This initiative will take the sub-networks -- government, education, the manufacturing sector, economic development organizations, and service -- and connect them. "The realization came that we're in these networks and we see the gap," says Schober. "We can connect those industries. So we get those collaboratons to solve a problem we've never solved before."

Several organizations have already shown support for the PRISM initiative, including Fund for Our Economic Future, The Cleveland Foundation, and the Greater Cleveland Partnership.


Source: John Schober
Writer: Karin Connelly

Shaker LaunchHouse, a pre-seed investment fund and business accelerator, has raised $250,000 in capital funds. A portion of the money will be used to invest an average of $10,000 in 15 software and disruptive technology companies. "Disruptive technology refers to thinking of things that shake up or dramatically change the market," explains Todd Goldstein, managing partner of SLH.

The investments will be made over the next 12 months. Additionally, SLH will provide office space and back office support to each of the 15 companies. Goldstein and his partner formed Shaker LaunchHouse in 2008 after seeing larger numbers of young entrepreneurs leaving Cleveland for cities that offered greater start-up opportunities.

"We saw a lot of young people moving away because there was a lot of seed money [elsewhere] ," explains Goldstein. "We felt that Cleveland was ripe for an organization that could provide seed money."

SLH's goal is to invest in 15 companies a year, while also providing networking with 100 mentors, cooperative office space and educational programming. SLH provides twice weekly workshops for entrepreneurs led by area business leaders with expertise in everything from how to manage the finances of a startup company to how to write an effective executive summary and make presentations as well as crash courses in website development.

SLH is in the process of moving into a renovated car dealership on Lee Road, which will provide 23,000 square feet of space for entrepreneurs and mentors.


Source: Todd Goldstein
Writer: Karin Connelly

Cleveland State University's Nance College of Business Administration and Shaker LaunchHouse have teamed up to encourage the regions entrepreneurs to follow their dreams.

The agreement was adopted at a special meeting of the Shaker City Council on March 14, after recommendation by the Shaker Heights Economic Development Department.

One of the first endeavors the two have launched is the 2011 Idea Competition. The contest is open to students at any Ohio college or university with an innovative business idea. Ideas should focus on software and Internet technology, low-tech medical devices, and clean energy.

"We really want to get the juices flowing of entrepreneurs in the region," says Shaker LaunchHouse managing partner Todd Goldstein. "We believe it's extremely important to provide an outlet for good ideas."

The winner gets a $2,500 scholarship to the Nance's global AMBA program and $1,000 from LaunchHouse, including incubation space, legal support, accounting support, and business planning assistance. The winner will have the chance to compete for $5,000 in seed funding.

Entry forms are due by noon on Monday, April 25. Finalists will then give a two-minute pitch to a panel of entrepreneurs and venture capitalists at Shaker LaunchHouse on Thursday, May 5. SLH will be offering educational seminars for the contestants to help them with their presentations.


Source: Todd Goldstein
Writer: Karin Connelly

Roe Green believes in the arts. She can't imagine a world without them, and she wants to make sure people in Northeast Ohio continue to be exposed to the latest in theater, music and dance at the Cleveland Play House. So she made a three-year, $500,000 commitment to FusionFest.

"To me it was a very exciting idea," Green says of the donation. "I like exposing people to new things. It's stuff like this at FusionFest that people would not otherwise see."

Green is honorary producer of the festival that has been celebrating new works since its inception in 2005. She also sits on Cleveland Play House board. "Arts are what make us human; without the arts we're nothing but machines," she says. "I said, 'this is something I can sink my teeth into.' This has become my baby because it perpetuates people doing new work."

Additionally, next year will mark the beginning of the annual Roe Green FusionFest Award. The $7,500 award will be given to a promising mid-career American playwright. "Having arts in the community is very important to the community," Green says, noting that for every dollar spent on theater tickets also means dollars spent for parking, food and other expenses associated with going to the theater.

The winner of the Roe Green Award will also receive script development support. The selected playwright will spend a week in residency at CPH during FusionFest, overseeing rehearsals and reading of the work and engage in workshops and master classes with young theatre artists from the region.


Source: Roe Green
Writer: Karin Connelly

JumpStart CEO Ray Leach has been named to the board of the National Venture Capital Association. The NVCA serves as the voice of the United States venture capital community and advocates for policies that encourage innovation and reward long-term investment.

While most of the organization's 400 members represent venture capital firms on the East and West coasts, Leach is the only member representing the Midwest. "In order to be successful as a non-profit, we need healthy venture capital nationally," says Leach. "It's a great way to be there, convincing them they have to invest in the Midwest."

Northeast Ohio leads the Midwest in venture capital deal activity, second only to Chicago in the amount of capital raised by companies with $234 million.

Leach is one of six new NVCA members elected to a four-year term. He was nominated by former NVCA board chair David Morgenthaler of Morganthaler Ventures and member Ray Lane with Kleiner Perkins, who thought Leach would be a good advocate for JumpStart's missives.

"I'm excited to play a role in advancing venture capital nationally and to offer my viewpoint from a region that's reinvented itself with the assistance of innovative initiatives like Ohio's state-led Third Frontier," says Leach. "For example, entrepreneurs in Northeast Ohio have raised more than $1.1 billion in venture capital in the last five years. By serving on the NVCA's board, I hope to bring greater visibility to our region's activity to increase investments and ultimately job growth."


Source: Ray Leach
Writer: Karin Connelly

Shannon Okey enjoys sharing what she knows about knitting. But she didn't like being told what to do by traditional publishers. So, after publishing 12 books the traditional way, Okey launched Cooperative Press in 2006 with The Knitgrrl Guide to Professional Knitwear Design, the first-ever business book targeted to the handknit industry.

"I decided to start my own company and take advantage of some of the things that larger publishers were ignoring or underusing, such as digital publications," says Okey. "We now publish in a variety of formats, including print, PDF and e-book reader formats."

Today, Okey runs her business out of the Lake Erie building at Templar Park in Lakewood. She is the only full-time employee, but she hires freelancers for everything from editing to photography to graphic design. Cooperative Press splits profits equally with its authors, and pays a higher percentage on digital publications.

The biggest hurdle Okey has overcome is financing. "Banks are terrified the second they hear the word 'knitting,'" she says. "Never mind that crafts are a billion-dollar-plus industry. Never mind we're totally in the black and doing great numbers. Our bank wouldn't give us a standard loan. Their underwriters offered up a credit card in its place -- not the same thing."

This month she launched a month-long campaign on Kickstarter to raise additional funds. The effort raised $6,500 in the first week of campaigning. It is now nearing $10,000.

"People believe in what we're doing and they want to see us succeed, so they're willing to give us money where traditional sources won't," says Okey. "I'm hoping we'll raise over $20,000 this month, which will allow us a lot more flexibility in terms of where we print and other factors."


Source: Shannon Okey
Writer: Karin Connelly

The Cuyahoga Arts and Culture (CAC) board recently approved a small grants pilot program for the 2012 funding cycle. The program simplifies the application process for organizations seeking funds up to $5,000.

The CAC's standard Project Support (PS) grant has an upper limit of $50,000 and requires a rigorous application process, including detailed financial and participant data, and a one-to-one cash match for each dollar of CAC funding. This program simplifies the amount of financial data required and allows for 25 percent of the match to be made up in "in kind" professional donations.

"The reason behind creating this program is small community-based non-profits don't have the resources to meet the financial requirements of the larger program," says CAC external affairs director Jonah Weinberg. "This should mean we're able to expand access to these projects throughout Cuyahoga County."

The guidelines for the grants will be available this month. Organizations can begin submitting intent to apply letters June 1. Applications will be reviewed by a public panel, and grants will be awarded at the CAC's November board meeting.

CAC grants are funded by a cigarette tax in Cuyahoga County earmarked for local arts and cultural funding. The CAC has awarded nearly $65 million since the ballot initiative was approved in 2006.


Source: Jonah Weinberg
Writer: Karin Connelly

Neuros Medical, a Greater Cleveland based medical device company, has developed a neuro-stimulator that has proven to eliminate chronic pain in amputees. A feasibility study, the first test on humans, showed the company's high-frequency Electrical Nerve Block™ technology reduced pain to zero in four of the five patients studied.

The device, which looks like a pacemaker attached to a wire, uses a high-frequency signal to stop the pain. "It will literally block that pain signal before it gets to the brain to be received," says Neuros president and CEO Jon Snyder. "Patients have complete numbness with no side effects or issues with addiction."

The technology was developed by Case Western Reserve University biomedical engineering professors Kevin Kilgore and Niloy Bhadra. The study was conducted by Dr. Amol Soin of the Kettering Health Network Innovation Center and the Ohio Pain Clinic in Dayton.

"It's amazing when you look at pain studies, and patients have a pain level of seven and you get down to four," Snyder says of other studies in pain reduction. "We had patients with a seven, eight or nine get down to zero. We had one patient sleep through the night for the first time in years."

The next step is to share the data with strategic partners and venture capital firms while doing long-term studies and further develop the technology. "It really keeps you motivated to keep going to get it to market," says Snyder of the results. "It's really meaningful."


Source: Jon Snyder
Writer: Karin Connelly

American Greetings has made it possible to send a loved one a greeting card with birthday candles to blow out -- literally. The new line of cards called Ready, Set, Blow features six scenarios in which recipients are prompted to blow on the card. The puff of air prompts the card to come to life with LED lights, a song and sounds.

Users blow on the cards to extinguish birthday candles, toot a horn, or make a wish on a dandelion. The cards are designed to please recipients of all ages, and they can be used again and again.

"Ready, Set, Blow lets people experience the birthday tradition of wishing in an innovative new way," says Carol Miller, executive director of new product concepts at American Greetings. "It's so much fun to see someone receive these cards because you get to watch their surprise as they open it and then their smile unfold as the card comes to life -- and hopefully, their wish granted."

The result is an interactive experience that is the next-best thing to actually being there. American Greetings launched the line in March at retailers nationwide. They sell for $6.99 each.


Source: Carol Miller
Writer: Karin Connelly

April and May bring out the best in design during the inaugural Cleveland Design Month-and-a-Half, which features two events that show off the talents of local design students as well as regional and national designers.

The Cleveland Institute of Art's annual Spring Design Show, a tradition for more than 20 years, kicks off on Tuesday, April 19, while the Cleveland Furniture Fair, hosted by Cleveland's District of Design, begins May 16.

In the spring show student work in industrial, interior and communication design will be on display for the public, as well as national employers in Case Western Reserve's Peter B. Lewis building. "More than 100 students show work and interview for internships," says CIA's head of industrial design, Dan Cuffaro. "It's a big job fair." A free public reception from 5:30 p.m. to 8 p.m. will kick off the event.

Throughout the week, designers hailing from some of the most progressive firms in the world will present a series of free lectures to the public.

The second annual Cleveland Furniture Fair will show off the brightest designers and manufacturers of furniture, lighting, millwork and more. This year's fair has a greater variety of designers from Northeast Ohio, unique seminars tailored specifically for exhibitors and the public, as well as pop-up retail shops and a variety of design-focused events.

Additionally, the American Institute of Architects (AIA) Cleveland Chapter has a calendar full of lectures, exhibitions, and tours open to the public that will introduce new and exciting architecture and design to Northeast Ohio.


Sources: Dan Cuffaro, Casey Burry
Writer: Karin Connelly

Thermalin Diabetes, a JumpStart Ventures portfolio company, recently closed $2.85 million in Series A investments, paving the way to the further development of short, medium and long lasting insulin analogs by Case Western Reserve Medical School Dr. Michael A. Weiss.

The announcement includes a second $250,000 investment from JumpStart, and exceeds Thermalin's original target by $1 million. "Having this round closed is great," says Thermalin CEO Rick Berenson. "I'm very excited about the progress. I'm looking forward to being able to report further progress."

The company is now moving immediately into Series B, in which the hope is to raise another $8 million. "With that we should be able to get through [the first] phases of studies."

The patents on existing insulins on the market are due to expire in 2013 and 2014, so the interest in Thermalin's developments is huge worldwide. Weiss' work centers around developing insulins that are more stable and effective on a more timely basis.

Thermalin has developed about 40 different analogs. The funding will allow the company to continue testing to determine which analogs to commercialize.

Insulin is a $14 billion a year market -- the largest volume drug market in the world. Insulin sales are expected to double in the U.S., triple in Europe and increase 12-fold elsewhere in the world as the disease reaches epidemic levels.

Thermalin employs six full time scientists at the Cleveland Clinic's Global Cardiovascular Innovation Center. The investment allows for additional key hires, including a senior scientist.


Source: Rick Berenson
Writer: Karin Connelly

Five years ago, Deby Cowdin was cleaning up after a party. As she picked up the empty wine and liquor bottles on her porch, her friend and partner, Mindy Bohannon, dared her to do something that would change her life. "She said, 'you're a glass artist, figure out something to do with them.'" So Cowdin did exactly that. She founded Blue Bag, a company that transforms bottles into serving plates, cheese boards and other works of art.

Cowdin started the business out of her home, selling her creations first at the North Union Farmers Market at Crocker Park, then at other farmers markets and art shows. The idea took off. "We started out of necessity, as a hobby," she says. "We never really thought it would turn into a manufacturing business."

Blue Bag sales have grown 50 percent each year since 2006. This year sales are up 100 percent. Aside from two additional partners, daughter Brandy Cooney and Jeff Nischwitz, the company has eight employees. Cowdin makes a point of hiring hard-to-place people, including a disabled vet and an employee with mild autism. "We build our company around helping people," Cowdin says.

Everything from the recycling to the distribution is done in house -- these days a studio on W. 14th St. and Berea Road -- and their products are available in more than 300 retail stores nationwide. Everything with the exception of one item is purchased locally.

"We work really hard at keeping everything in Cleveland," Cowdin says. "If we don't support the local economy, who will?"


Source: Deby Cowdin
Writer: Karin Connelly

Local food startups are growing by leaps and bounds in Cleveland. Whether it's urban farming or specialty food production, the ability of local entrepreneurs to affect change in the food industry seems limitless.

This Monday, April 4, 10 food entrepreneurs will gather at Great Lakes Brewing Co. to share the secrets of their success. A Local Food Cleveland event, the Local Food Startup Business Showcase looks at businesses that are helping the local food economy.

Among the startups at the showcase will be Tunnel Vision Hoops, which designs retractable domes for year-round farming; Green City Growers Cooperative, a 100-percent worker-owned commercial greenhouse in Cleveland; and MOHCO, a manufacturer of falafel dough with a philanthropic mission to help communities locally and abroad.

And just in case you think this local food business isn't getting noticed outside of Cleveland, consider this: Yahoo! recently named Cleveland the fourth most visionary city in the world, particularly because of urban farming initiatives. Cleveland was ranked behind Seoul, Abu Dhabi and Tallinn, Estonia. The online news source sited Gardens Under Glass in the Galleria, which grows vegetables and then sells them at a weekly indoor market, as a fine example of urban farming in Cleveland.


SOURCE: Local Food Cleveland
WRITER: Diane DiPiero

MMPI, owner and operator of the forthcoming Medical Mart & Convention Center, stands to save $5 million over 14 years thanks to a newly signed contract with Cleveland Thermal. Rather than build its own on-site heating and cooling system, the mart and convention center will use heating and cooling energy provided by Cleveland Thermal.

Cleveland Thermal is a district energy supplier that serves about 125 commercial, institutional, municipal and federal buildings in Cleveland. The 117-year-old company delivers thermal heat and chilled water through underground pipes that connect to Cleveland Thermal's power plant.

Cleveland Thermal's infrastructure was technically already in place to serve the mart and convention center. According to the company, the existing piping has been disconnected to allow for safe demolition of the old buildings. The new facility will be reconnected to the heating and cooling system later this year.

Cleveland Thermal, which employs 47 people, would not disclose the amount of the contract with MMPI.

Karpinski Engineering, which is handling mechanical system and mapping for the new facility, recommended Cleveland Thermal. Dennis Wessel, senior vice president, points out that MMPI will not have to worry about installing and operating onsite heating and cooling equipment, which will save money. What's more, Wessel says. "this arrangement will enable MMPI to allocate valuable additional floor space to other uses."

MMPI also recently announced that it will seek LEED Silver Certification for the facility, a designation determined by the U.S. Green Building Council. Using an existing heating and cooling source will lessen the environmental impact of the new facility, according to MMPI.


SOURCES: Cleveland Thermal, Karpinski Engineering, MMPI
WRITER: Diane DiPiero

Cleveland-based ChanTest has tested more than 20,000 compounds for hundreds of pharmaceutical and biotech companies around the world since its founding in 1998. Over the years, the company has also developed a cell optimization service. These advancements have helped pharmaceutical and biotech companies develop safer drugs for a variety of health-related issues.

ChanTest has now formed an agreement with Molecular Devices, a Sunnyvale, California, company, to further its impact on the industry. Molecular Devices will distribute ChanTest's ion channels and promote its cell optimization services to a number of global customers.

Dr. Arthur Brown, founder of ChanTest, says that this partnership will benefit ChanTest because of the screening instrumentation provided by Molecular Devices. These include automated electrophysiology devices, which study the effects of electric activity in the body. "The ability to screen ion channels with automated electrophysiology is revolutionizing drug discovery," according to Dr. Brown.

ChanTest has a staff of 70 people, including scientists specializing in molecular and cell biology, chemistry and electrophysiology.


SOURCE: ChanTest
WRITER: Diane DiPiero