University Circle
More than 16,000 people in the United States are on the waiting list for a liver transplant, yet 10,000 die before they get one. Cleveland Clinic transplant surgeon Koji Hashimoto has spent the last nine years researching the practice of splitting a donor liver between two recipients, thus reducing demand.
“There’s a big gap between supply and demand,” explains Hashimoto. “In many smaller recipients, the liver is too large. You can’t transplant a large liver into a small patient. So we can split the liver.”
Hashimoto performed split liver transplants in 25 patients in his study, which was published in the July American Journal of Transplantation. Some of Hashimoto’s patients received the left lobe of the liver, some received the right lobe. Two patients benefitted from one liver donated.
“The survival was the same as whole liver transplants,” says Hashimoto. “We’ve had an 80 percent survival rate after five years.”
Only a handful of hospitals are actively performing split liver transplants, with the Cleveland Clinic being one. “Many centers don’t do it because you have to have lots of people on the team and it’s very challenging,” Hashimoto explains. “With a split liver transplant you have two patients receiving livers at the same time. You have to divide the blood vessels too -- sometimes using microscopes in the transplant -- and one surgeon goes out to split the liver in the donor body.”
While the split liver allows surgeons to place an organ in smaller patients, such as children, larger patients benefit as well. “The liver is the only organ that can regenerate in the body,” says Hashimoto. “Eventually the liver will grow to the size to fit the patient.”
“There’s a big gap between supply and demand,” explains Hashimoto. “In many smaller recipients, the liver is too large. You can’t transplant a large liver into a small patient. So we can split the liver.”
Hashimoto performed split liver transplants in 25 patients in his study, which was published in the July American Journal of Transplantation. Some of Hashimoto’s patients received the left lobe of the liver, some received the right lobe. Two patients benefitted from one liver donated.
“The survival was the same as whole liver transplants,” says Hashimoto. “We’ve had an 80 percent survival rate after five years.”
Only a handful of hospitals are actively performing split liver transplants, with the Cleveland Clinic being one. “Many centers don’t do it because you have to have lots of people on the team and it’s very challenging,” Hashimoto explains. “With a split liver transplant you have two patients receiving livers at the same time. You have to divide the blood vessels too -- sometimes using microscopes in the transplant -- and one surgeon goes out to split the liver in the donor body.”
While the split liver allows surgeons to place an organ in smaller patients, such as children, larger patients benefit as well. “The liver is the only organ that can regenerate in the body,” says Hashimoto. “Eventually the liver will grow to the size to fit the patient.”
Case Western Reserve University has opened the new Tinkham Veale University Center just in time for the start of the school year. In the coming weeks, six new eateries will be unveiled. The addition of mouthwatering new venues like Melt University, the latest from Matt Fish of Melt Bar & Grilled fame; Naan, an Indian venue by James Beard Award nominee Chef Raghavan Iyer; and Cool Beanz, which will serve Zingerman's Coffee out of Ann Arbor, are enough to make us want to go back to school.
Fortunately, we won't have to. All of the venues are open to the public, and the soon-to-be-named restaurant (a student contest will determine its name) will serve a prix fixe menu when the orchestra plays in town. Cleveland Botanical Garden Executive Chef Tony Smoody will serve as chef of the restaurant.
Additional eateries include 8Twenty6, where customers can build their own salad from an eight-foot counter stocked with 20 seasonal ingredients and six housemade dressings, and Pinzas, which serves personal pizzas, pasta bowls and Italian sandwiches served on pagnotelle rolls. Melt University will serve items off the Melt Bar & Grilled menu as well as "exclusive CWRU-themed sandwiches only available at Melt U, the Case Western BBQ and The Spartan Burger," according to a press release from Bon Appetit Management, the food service company.
"This is an opportunity to showcase the beauty of regional Indian cooking," said Iyer during a recent visit to the university center. "What you typically see in the U.S. is just a sliver of Indian cooking, and what I bring is multi-regional cooking."
CWRU has a large population of foreign-born students, so the ethnic diversity of these options will no doubt prove popular. The university has not only transformed its physical environment in recent years, adding student amenities that create a more vibrant campus, but has also seen a dramatic increase in enrollment.
Previously, there was no full-service restaurant on the CWRU campus, and dining options were a bit limited. These six new eateries add to the increasing vibrancy that can be found on campus and throughout University Circle.
Fortunately, we won't have to. All of the venues are open to the public, and the soon-to-be-named restaurant (a student contest will determine its name) will serve a prix fixe menu when the orchestra plays in town. Cleveland Botanical Garden Executive Chef Tony Smoody will serve as chef of the restaurant.
Additional eateries include 8Twenty6, where customers can build their own salad from an eight-foot counter stocked with 20 seasonal ingredients and six housemade dressings, and Pinzas, which serves personal pizzas, pasta bowls and Italian sandwiches served on pagnotelle rolls. Melt University will serve items off the Melt Bar & Grilled menu as well as "exclusive CWRU-themed sandwiches only available at Melt U, the Case Western BBQ and The Spartan Burger," according to a press release from Bon Appetit Management, the food service company.
"This is an opportunity to showcase the beauty of regional Indian cooking," said Iyer during a recent visit to the university center. "What you typically see in the U.S. is just a sliver of Indian cooking, and what I bring is multi-regional cooking."
CWRU has a large population of foreign-born students, so the ethnic diversity of these options will no doubt prove popular. The university has not only transformed its physical environment in recent years, adding student amenities that create a more vibrant campus, but has also seen a dramatic increase in enrollment.
Previously, there was no full-service restaurant on the CWRU campus, and dining options were a bit limited. These six new eateries add to the increasing vibrancy that can be found on campus and throughout University Circle.
When doctors perform surgical procedures, they typically use cold surgical irrigation fluid to expand the patient’s body cavity. The cold fluid can increase their risk of hypothermia, which in turn leads to three times the risk of surgical site infections and other complications.
Now hospitals like the Cleveland Clinic and University Hospitals have turned to a local company for a solution. Thermedx has developed the first smart surgical irrigation device to provide fluid warming in arthroscopic and hysteroscopic procedures.
“We developed a smart version of an irrigation pump,” explains Thermedx co-founder and executive vice president Mike Haritakis. “It’s a touchscreen, multi-functional irrigation pump that can actually allow a procedure to be done with one device”
The Thermedx’s Fluid Smart System, which is used primarily in endoscopic and laparoscopic gynecological, urological and orthopedic procedures, pressurizes the body cavity safely during surgery to improve visibility, warms the irrigation fluid and monitors the fluids and prevents hypothermia.
“It really consolidates the devices and streamlines the staff in the OR,” explains Angela Dubik, clinical services manager. “The end result is it makes surgeons’ and nurses’ jobs much easier, it saves the hospital money and it improves patient care.”
Thermedx developed the Fluid Smart System in part through funding from Third Frontier and BioEnterprise. The company employs 18 people and is growing. “We’re just looking to continue to develop new products,” says Haritakis. “We want to continue to add jobs to support Northeast Ohio growth in the medical device community. We’re all about growth, essentially.”
Now hospitals like the Cleveland Clinic and University Hospitals have turned to a local company for a solution. Thermedx has developed the first smart surgical irrigation device to provide fluid warming in arthroscopic and hysteroscopic procedures.
“We developed a smart version of an irrigation pump,” explains Thermedx co-founder and executive vice president Mike Haritakis. “It’s a touchscreen, multi-functional irrigation pump that can actually allow a procedure to be done with one device”
The Thermedx’s Fluid Smart System, which is used primarily in endoscopic and laparoscopic gynecological, urological and orthopedic procedures, pressurizes the body cavity safely during surgery to improve visibility, warms the irrigation fluid and monitors the fluids and prevents hypothermia.
“It really consolidates the devices and streamlines the staff in the OR,” explains Angela Dubik, clinical services manager. “The end result is it makes surgeons’ and nurses’ jobs much easier, it saves the hospital money and it improves patient care.”
Thermedx developed the Fluid Smart System in part through funding from Third Frontier and BioEnterprise. The company employs 18 people and is growing. “We’re just looking to continue to develop new products,” says Haritakis. “We want to continue to add jobs to support Northeast Ohio growth in the medical device community. We’re all about growth, essentially.”
As the 2014 Gay Games play out with eclectic events all over town, it becomes clear how they will leave a lasting positive effect on the host city of Cleveland. Uniting beneath a banner of inclusion, collaboration and unity, participants and sponsors establish a spirit that will endure long after the lights have dimmed and the last athlete has left the track.
cleveland museum of art enjoys most visitors in years
On the heels of its multiyear, $320 million renovation and expansion project, the Cleveland Museum of Art is already reaping big gains. Nearly 600,000 visitors came to the museum between July 1, 2013, and June 30, 2014, which was the highest in over a decade and represented a 19% increase over the previous fiscal year.
Museum membership, meanwhile, increased 18% to 23,094, with more than 3,300 new introductory-level members.More than $46 million was raised to support museum operations and programs.
“We are gratified by the continued growth in attendance and membership support, which clearly reflects the excitement being generated by our outstanding new facilities and programming,” said Fred Bidwell, the museum’s interim director.
Read all about the good news here.
Museum membership, meanwhile, increased 18% to 23,094, with more than 3,300 new introductory-level members.More than $46 million was raised to support museum operations and programs.
“We are gratified by the continued growth in attendance and membership support, which clearly reflects the excitement being generated by our outstanding new facilities and programming,” said Fred Bidwell, the museum’s interim director.
Read all about the good news here.
Welcome to the latest round of Lab Chat, in which our resident Post-Doctoral Research Associate attempts to demystify the complex world of biomedical research. Today, our writer takes on the roadblocks to diagnosing and treating cancer -- and how improvements in medical technology are offering avenues to better results.
For those who have suffered a traumatic injury to the skull and face -- be it from an accident, cancer or deformity -- OsteoSymbionics leads the way in facial reconstruction. The Cleveland-based manufacturer of custom craniofacial implants serves surgeons at hospitals across the United States. OsteoSymbionics’ products provide both skull rebuilding and is cosmetically attractive.
Founded in 2006by Cynthia Brogan, OsteoSymbionics is known for using a special plastic in its craniofacial implants that doesn’t break and exactly fits the patient's face or skull. “We’re a well-respected player in the marketplace,” says CEO Dorothy Baunach. “The type of plastic we use is a market niche and it’s done really well in its ability to be shaped to the skull opening without crumbling or breaking.”
Today, OsteoSymbionics has a line of products that range from a clear implant that allows surgeons to see brain function during placement, to hard and soft tissue implants. Housed in the Incubator at MAGNET, the company employs six full-time and two part-time employees who have backgrounds that range from medical artists and sculptors to biomedical engineers and materials scientists.
Many of the artists on staff are graduates of Cleveland Institute of Art’s biomedical program. “They’re really our secret weapon,” says Baunach. “The fit and forming is more of an art than a science. Because of the talent of the students at CIA, they can do things that are pretty complex.”
Baunach plans to double sales by the end of the year and add sales reps across the country. “It’s really about growing sales and the company,” she says. “Sales are built on surgeons’ preferences.”
Founded in 2006by Cynthia Brogan, OsteoSymbionics is known for using a special plastic in its craniofacial implants that doesn’t break and exactly fits the patient's face or skull. “We’re a well-respected player in the marketplace,” says CEO Dorothy Baunach. “The type of plastic we use is a market niche and it’s done really well in its ability to be shaped to the skull opening without crumbling or breaking.”
Today, OsteoSymbionics has a line of products that range from a clear implant that allows surgeons to see brain function during placement, to hard and soft tissue implants. Housed in the Incubator at MAGNET, the company employs six full-time and two part-time employees who have backgrounds that range from medical artists and sculptors to biomedical engineers and materials scientists.
Many of the artists on staff are graduates of Cleveland Institute of Art’s biomedical program. “They’re really our secret weapon,” says Baunach. “The fit and forming is more of an art than a science. Because of the talent of the students at CIA, they can do things that are pretty complex.”
Baunach plans to double sales by the end of the year and add sales reps across the country. “It’s really about growing sales and the company,” she says. “Sales are built on surgeons’ preferences.”
Artists are often the first to move into urban neighborhoods, and also the first to move out when rents escalate. Yet in the post-recession landscape, many communities are working with artists to transform blight, engage residents and reimagine their neighborhoods.
There has been a flood of new businesses that tout the city through an assortment of Cleveland-themed apparel and products or by integrating the city name right into the company’s branding. Many point to the recent recession as the dawn of this entrepreneurial movement, which coincided with a newfound pride of place.
university study ranks cities' walkability; cleveland in top 10
In a recently released report by the Center for Real Estate and Urban Analysis at George Washington University School of Business in conjunction with Smart Growth America, the 30 largest U.S. cities were ranked by how walkable they are. This is key indicator on how cities are shifting from suburban sprawl to urban infill.
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“The researchers, including Leinberger, first looked at Walkscore heat maps, focusing on areas that scored high. They then looked at areas with significant regional importance, meaning they have at least 1.4 million square feet of office space and more than 340,000 square feet of retail space. They combined these factors to determine areas they call "walkable urban places" or WalkUPs.”
But the report doesn’t just evaluate the present; it looks ahead.
“Researchers then tried to predict how these areas would grow in the future by looking at trend lines and pricing premiums in rent space, which indicate demand level. For example, demand around train stations in places like Washington, D.C. is so high commercial and residential renters can pay a premium of between 50 and 80 percent, said Emerick Corsi, president of Cleveland-based Forest City Enterprises Real Estate Services.
Coming in at No. 10 is Cleveland.
“Ohio's largest city hangs on to the bottom spot in the Top 10, but that may change soon. It's set to plummet to No. 24 in the future. Cleveland is one of a handful of older industrial cities where walkability is largely rooted in the past, where a strong city center is walkable while the rest of the surrounding suburban area lacks any kind of walkable urban space.”
Read the rest here.
?
“The researchers, including Leinberger, first looked at Walkscore heat maps, focusing on areas that scored high. They then looked at areas with significant regional importance, meaning they have at least 1.4 million square feet of office space and more than 340,000 square feet of retail space. They combined these factors to determine areas they call "walkable urban places" or WalkUPs.”
But the report doesn’t just evaluate the present; it looks ahead.
“Researchers then tried to predict how these areas would grow in the future by looking at trend lines and pricing premiums in rent space, which indicate demand level. For example, demand around train stations in places like Washington, D.C. is so high commercial and residential renters can pay a premium of between 50 and 80 percent, said Emerick Corsi, president of Cleveland-based Forest City Enterprises Real Estate Services.
Coming in at No. 10 is Cleveland.
“Ohio's largest city hangs on to the bottom spot in the Top 10, but that may change soon. It's set to plummet to No. 24 in the future. Cleveland is one of a handful of older industrial cities where walkability is largely rooted in the past, where a strong city center is walkable while the rest of the surrounding suburban area lacks any kind of walkable urban space.”
Read the rest here.
Everybody has those days when they just don’t feel like going to work. But some employers offer perks that make coming to work a little less painful. From all-you-can-eat snack bars to pursuing outside interests on company time -- and free beer! -- these companies help make coming to the office a little easier to swallow.
philanthropist's efforts to boost young audiences at orchestra in new york times
In a New York Times post titled, "Maintaining a Classical-Music Miracle in Cleveland," writer Craig Duff covers efforts by local philanthropist Milton Maltz to increase the number of young audience members at Cleveland Orchestra performances.
"When Milton Maltz looked down from his box seat in Severance Hall -- the stately home of the Cleveland Orchestra -- he used to fear for its future," writes Duff.
"Where are the young people?" Maltz is quoted in the article.
The aging of audiences is something all orchestras are contending with, but Maltz decided to do something about it. He and his wife donated $20 million to help the orchestra build a younger audience, with the ambitious goal of attracting the youngest audience of any orchestra in America by 2018, the band's 100th birthday.
Incentives include "FanCards" that allow young concertgoers to attend as many concerts as they like per season for $50. Additional deals include free admission to summer outdoor concerts at Blossom for those under age 18. Students also can attend any concert during the subscription season for $10.
Efforts are paying off: in 2010, students made up 8 percent of the audience. Last year, that figure was 20 percent.
Read the rest of the good news here.
"When Milton Maltz looked down from his box seat in Severance Hall -- the stately home of the Cleveland Orchestra -- he used to fear for its future," writes Duff.
"Where are the young people?" Maltz is quoted in the article.
The aging of audiences is something all orchestras are contending with, but Maltz decided to do something about it. He and his wife donated $20 million to help the orchestra build a younger audience, with the ambitious goal of attracting the youngest audience of any orchestra in America by 2018, the band's 100th birthday.
Incentives include "FanCards" that allow young concertgoers to attend as many concerts as they like per season for $50. Additional deals include free admission to summer outdoor concerts at Blossom for those under age 18. Students also can attend any concert during the subscription season for $10.
Efforts are paying off: in 2010, students made up 8 percent of the audience. Last year, that figure was 20 percent.
Read the rest of the good news here.
Welcome to the latest round of Lab Chat, in which we try to demystify the often complex field of biomedical research. Today, our well informed post-doc takes on commercial drug development, specifically, why the heck does it take so long for prescription drugs to move from lab to local pharmacy?
The entrepreneurs behind Piccadilly Artisan Yogurt have unveiled the concept behind their new shop in University Circle. The Cleveland-based company's latest location, Piccadilly Artisan Creamery, will feature a style of ice cream and yogurt that is made using liquid nitrogen to rapidly freeze small batches of delicious ice cream.
This process of using liquid nitrogen to instantly craft yogurt and ice cream has grown rapidly on the West Coast, but Piccadilly is the first company in Cleveland to employ the technique. The process has three main benefits, say founders Adrian and Cosmin Bota: the rich and creamy texture it gives the frozen treats, the customization afforded to the customer, and the lack of preservatives needed when making it.
It all begins with the liquid nitrogen, which boils at an astounding -321 degrees Fahrenheit (that's several degrees colder than it was during the recent Polar Vortex). The nitrogen is added to the other ice cream ingredients in a mixer, where the nitrogen instantly freezes the contents on contact.
“We're really gonna let people go crazy and create their own thing,” Adrian explained during a demonstration on Thursday evening. Customers can decide what goes into their yogurt or ice cream and how soft or hard the texture will be. Because the ice cream or yogurt is being prepared fresh for each customer, preservatives are never necessary, which the owners claim results in a better-tasting product.
The Botas teamed up with designer Sailee Gupte, who helped transform the new store on Euclid. The tables and countertops are made of thick slabs of raw, live-edge wood. Exposed brick on walls gives the shop an edgy, urban feel. “Each area [Piccadilly] moves into has a specific feel and we want to pay homage to that," Sailee explained. To pay tribute to University Circle, the owners opted for “a more vintage and rustic theme.”
Piccadilly's owners have a passion for local, organic food that is evident in the menu offerings at their existing locations in Cleveland Heights and Ohio City. The owners buy from a local farm that does not use any preservatives, hormones or antibiotics, and they source other ingredients from the West Side Market. The Botas also will offer vegan yogurt options in the University Circle store.
“We’re just excited to be a part of this neighborhood," Bota told those in attendance.
The official grand opening of the new Piccadilly in University Circle is May 24th.
There's more than one way to get around Cleveland. As more and more alternative transportation options like Lyft, Uber and pedicabs enter the local market, residents are discovering that it's increasingly becoming easier to leave the wheels at home. Fresh Water took them for a test drive.
introducing cleveland, the 'entertainment capital you never knew about'
In a Travelers Today feature titled "Five Reasons Cleveland is the Entertainment Capital You Never Knew About,' writer Will Walker calls our fair city "one of largest and most underrated cultural hot-spots in the country."
According to Walker, here are five reasons Cleveland is the entertainment capital that's "ripe for exploration by any traveler adventurous enough to take a chance on it."
Rock and Roll Hall of Fame
"Opened in 1995 by Atlantic Records founder Ahmet Ertegun, the Rock Hall marks a must-see destination for anyone interested in Rock & Roll, music, or pop culture in general.
Cinematheque
The Cleveland Institute of Art's Cinematheque offers what the New York Times called one of the country's "best repertory movie theaters."
Cleveland Museum of Art
Cleveland has one of the "best and most important art museums in the country, boasting works from artists as diverse as Caravaggio, David, and Monet."
Playhouse Square
"The second largest theatrical complex in the country (outside of New York) Playhouse Square's nine theaters sprawl over two city blocks, casting an impressive shadow of cultural sophistication that the rest of the city can't help but take note of."
Cleveland Orchestra
According to the British music periodical Gramophone, the Cleveland Orchestra ranks as the seventh best in the world, topping every single United States orchestra outside of Chicago.
Read the rest of the good news here.
According to Walker, here are five reasons Cleveland is the entertainment capital that's "ripe for exploration by any traveler adventurous enough to take a chance on it."
Rock and Roll Hall of Fame
"Opened in 1995 by Atlantic Records founder Ahmet Ertegun, the Rock Hall marks a must-see destination for anyone interested in Rock & Roll, music, or pop culture in general.
Cinematheque
The Cleveland Institute of Art's Cinematheque offers what the New York Times called one of the country's "best repertory movie theaters."
Cleveland Museum of Art
Cleveland has one of the "best and most important art museums in the country, boasting works from artists as diverse as Caravaggio, David, and Monet."
Playhouse Square
"The second largest theatrical complex in the country (outside of New York) Playhouse Square's nine theaters sprawl over two city blocks, casting an impressive shadow of cultural sophistication that the rest of the city can't help but take note of."
Cleveland Orchestra
According to the British music periodical Gramophone, the Cleveland Orchestra ranks as the seventh best in the world, topping every single United States orchestra outside of Chicago.
Read the rest of the good news here.
Sometimes, even the most adventurous resident can grow a little too comfortable living in the same city after a while. But one can always find something new to discover if we just dig a little deeper. Lucky for us, a number of smartphone apps will help the explorer in all of us get reacquainted with the city we call home.
It's been four and a half years since the first edition of "Moon Handbooks: Cleveland" was published. Considering all that has taken place in Cleveland during that time, author and Fresh Water managing editor Douglas Trattner says that for the second edition, which was released this week, he went back to the starting gate.