For decades, the heart of University Circle was lifeless after 5 p.m. Uptown, a $65 million development of new shops, restaurants, markets and apartments, aimed to change that by becoming a new center of gravity for Cleveland’s cultural district. So, now that it’s halfway completed, how is Uptown doing?

Cleveland Clinic Innovations (CCI) has named seasoned Health Information Technology (HIT) veteran Gary Fingerhut as its new executive director. Fingerhut has more than 30 years of experience as an entrepreneur in IT, co-founding a global software company and as a senior executive of a software development and technology consulting firm.

CCI is the commercial arm of the Cleveland Clinic, responsible for company creation and business development of medical technology develo... Read more >

If you were among the thousands of people who attended concerts this summer outside the Transformer Station in Ohio City, you have Thomas Welsh to thank. As director of the Cleveland Museum of Art's newly minted City Stages, the Philadelphia native is spicing up his new hometown with musical acts from around the globe.

Once ground zero for all things rock 'n' roll, Cleveland has steadily shed its reputation as King, and in the process squandered many of the economic benefits that go along with it. An effort by local advocates is attempting to change that by raising the industry’s profile and marketing it to a wider audience.

Abeona Therapeutics, a small biotech startup company that develops therapies for lysomal storage diseases, earned the Global Gene’s Champion of Hope award, along with its partners, for its work in developing therapies for children with Sanfilippo Syndrome, a rare genetic disorder.
 
Abeona, founded earlier this year in Cleveland as a spinoff of Columbus-based Nationwide Children’s Hospital, is developing two products that came out of research at Nationwide... Read more >

Once the province of sculptors, public art has evolved into an essential element of urban placemaking and social engagement. From murals on vacant buildings to art in laundromats to edible art installations that are as mouthwatering as they are aesthetically pleasing, we take a look at how public art is transforming our cities.

“We’re shifting because the times are shifting,” says Grace Gallucci of NOACA, adding that the planning agency will shift its focus to multimodal transportation, developing a fix-it-first approach that prioritizes existing infrastructure over new road projects, and basing funding decisions on their regional economic development impact.

The Cleveland Clinic marks its 50th year of successful kidney transplants this year. While the Clinic was not the first to successfully transplant a human kidney, the hospital was, and continues to be, a pioneer in the field.

“There were two earlier transplants,” explains Robert Heyka, interim chair of the department of nephrology and hypertension at the Clinic’s Glickman Urological and Kidney Institute. “One was in New Jersey, but it only lasted 1... Read more >

Starting a successful food-based business takes more than a great idea and the ability to cook. Like any entrepreneurial venture, food startups require planning, money and a willingness to be flexible. But those who do dive in have found there's plenty of guidance, support and collaboration in the local food startup community.

WMMS "The Buzzard" reached the largest radio audience in the history of Cleveland media. A new film hopes to document the glory years when a charmed roster of on-air talent introduced national rock acts like Bruce Springsteen, David Bowie and Joe Walsh to the people of Cleveland and the rest of the country.

Researcher J. Mark Brown and his team at the Cleveland Clinic Lerner Research Institute have discovered a protein that might promote obesity and diabetes. Therefore, blocking that protein, called ABHD6, might prevent these diseases.

ABHD6 regulates the brain’s endocannabinoid system, which is involved in metabolism, cravings and hunger.
 
Brown discovered ABHD6’s role in fat storage while studying a mutation in a different protein in the same grou... Read more >