Welcome to the latest round of Lab Chat, in which our resident Post-Doctoral Research Associate attempts to demystify the complex world of biomedical research. Today, our writer takes on the roadblocks to diagnosing and treating cancer -- and how improvements in medical technology are offering avenues to better results.

For those who have suffered a traumatic injury to the skull and face -- be it from an accident, cancer or deformity -- OsteoSymbionics leads the way in facial reconstruction. The Cleveland-based manufacturer of custom craniofacial implants serves surgeons at hospitals across the United States. OsteoSymbionics’ products provide both skull rebuilding and is cosmetically attractive.
 
Founded in 2006by Cynthia Brogan, OsteoSymbionics is known for using a special plastic in its craniofacial implants that doesn’t break and exactly fits the patient's face or skull. “We’re a well-respected player in the marketplace,” says CEO Dorothy Baunach. “The type of plastic we use is a market niche and it’s done really well in its ability to be shaped to the skull opening without crumbling or breaking.”
 
Today, OsteoSymbionics has a line of products that range from a clear implant that allows surgeons to see brain function during placement, to hard and soft tissue implants. Housed in the Incubator at MAGNET, the company employs six full-time and two part-time employees who have backgrounds that range from medical artists and sculptors to biomedical engineers and materials scientists.
 
Many of the artists on staff are graduates of Cleveland Institute of Art’s biomedical program. “They’re really our secret weapon,” says Baunach. “The fit and forming is more of an art than a science. Because of the talent of the students at CIA, they can do things that are pretty complex.”
 
Baunach plans to double sales by the end of the year and add sales reps across the country. “It’s really about growing sales and the company,” she says. “Sales are built on surgeons’ preferences.”
 

Joanie Nelson and her granddaughter Jayda live in the new Fairfax Intergenerational Housing development on Cedar Avenue between E. 80th and 83rd streets. Eight years back, Joanie's daughter was struck and killed by a drunk driver in a car accident, leaving Joanie to raise her granddaughter. It's hard to raise a grandchild as a senior, of course, yet this challenge is made easier by the new housing development, which offers social workers, a computer lab and other support services that are aimed at helping grandparents who are raising grandkids.

“My granddaughter and I are thrilled with our new home at Fairfax Intergenerational," Nelson said in a press release. "I’m excited that the school and church are very close, and we have access to a computer center and after-school activities."

There are 2.4 million grandparents raising 4.5 million kids in the U.S. Fairfax Intergenerational Housing, now named Griot Village, is the first project of its kind in Ohio and one of only seven in the country. It offers an affordable, sustainable and supportive environment for seniors 55 and older who are raising children.

Griot Village was designed in accordance with Enterprise Green Community standards. The development consists of 40 new townhomes with a shared courtyard that promotes a sense of community. A Supportive Services Coordinator provides onsite services to residents. There are eight buildings, each of which has five housing units. Each unit offers homework stations and play areas, and there's an onsite community center. The new residents are in close proximity to a commercial and retail development, walking distance to University Circle, and a short distance from several major medical centers and local schools.

"This development allows grandparents to be in an environment where they can be free with fact that they’re raising a child," says Jeffrey Patterson, CEO of CMHA. "You may have seniors who live in one of our senior buildings and are taking on that role, but our senior buildings were not built for that purpose. Here, there’s play equipment on the property. There's a community center where there are educational opportunities. It's in an area that provides good development opportunities for youth and seniors. We can help them to be successful."

The total project investment amount was $12 million, which was funded primarily by Low Income Housing Tax Credits. The development is a partnership between CMHA and Fairfax Renaissance Development Corporation.
 

Jodi Rae Santosuosso grew up in the restaurant business, working in her parents' Italian restaurant. She later moved to California for 10 years, where she grew enamored of the healthy living movement and got into cold-pressed juices. When she returned to Cleveland to join the revitalization of her hometown, she discovered that there weren’t many juice bars in the city, so she decided to launch her own.

If all goes as planned, Daily Press, a juice bar and vegan café, will open next month in the Gordon Square Arts District (6604 Detroit Ave.). The cafe will serve cold-pressed juices and vegan menu items that include raw sandwiches, soups and salads. Daily Press will open at 7 a.m., with evening hours yet to be determined.

"I want to help people be healthy and feel good, and to make it easy and convenient for people to do that," says Santosuosso. "This is new to Cleveland, but the market is here; people are just not aware of the benefits of juicing this way."

Cold-press juicing is different from tossing fruit in a blender and grinding it up, she explains. The heat from a centrifugal juicer can destroy natural enzymes in the drink, making it less nutritious. There are two steps in the cold-pressing process: First, you turn the produce into pulp so that the vitamins and other good stuff stays intact. Second, you put the pulp into a bag and place it in a hydraulic press, where 2,000 pounds of pressure releases all that sweet goodness.
"The result is delicious juice that has all kinds of good things for your body," she says.

Some of Daily Press's offerings will include the Johnny Apple Manziel (apple, ginger and lemon), Greenest Cleanse (kale, spinach, chard, parsley, cucumber, ginger and turmeric) and Water You Doing? (watermelon). A 16-ounce juice in a glass jar will sell for $7-9. If you bring back the jar, you get $1 off your next juice.

The 800-square-foot storefront will have a bar that seats five to six people, additional window seating and some outside tables. There will be Wi-Fi access for anyone who wants to work at the cafe. Santosuosso is looking forward to joining the neighborhood.

"I love the neighborhood and the arts district, and Detroit Shoreway Community Development Organization was really excited about having me come to this space," she says. "It helped that the neighborhood wants me here."

If you're interested in checking out Daily Press before the cafe opens, Santosuosso will be at the Gordon Square Farmers Market for the next few weeks, and she invites you to come by and learn more about juicing.

Everybody has those days when they just don’t feel like going to work. But some employers offer perks that make coming to work a little less painful. From all-you-can-eat snack bars to pursuing outside interests on company time -- and free beer! -- these companies help make coming to the office a little easier to swallow.

Welcome to the latest round of Lab Chat, in which we try to demystify the often complex field of biomedical research. Today, our well informed post-doc takes on commercial drug development, specifically, why the heck does it take so long for prescription drugs to move from lab to local pharmacy?
 

Eugene Malinskiy already is on his third startup and he's not even 30 yet. He created his first company when he was 16, later selling both for a profit. Now he's launched Dragon ID, a healthcare innovation and design firm that has grown from zero to 20 employees in the span of just two years.

Dragon ID is a biomedical startup that helps doctors and hospitals solve healthcare problems. The firm focuses on the medical device, health IT and surgery markets, and has a cross-functional team of whizzes to help healthcare professionals create solutions. The Dragon ID team is working on a number of products, but one that's getting buzz is EuCliD, which will be used in transcatheter aortic valve replacements to help prevent emboli from breaking away and causing blood clots or strokes.

Recently, Dragon ID moved from Shaker Launchhouse to the Heights Rockefeller building, where it is currently customizing its own space, including a lab, to accommodate growth. Malinskiy says the firm will benefit from having more professional offices and a location that's closer to where employees live.

"The City of Cleveland Heights was very welcoming," he says, referencing financial incentives that helped seal the deal. "They really want us here."

Malinskiy attributes Dragon ID's growth to the booming healthcare sector in Cleveland, where he can do business with the Clinic and other big players. "Being here, companies can come to us and say, 'We have this idea, what can you do?'"

Typically, Malinskiy and his cohorts receive an inquiry, then spend time vetting it, including attending surgeries, to understand the scope of the problem and potential solution. Once a solution is identified, the team builds a digital or physical prototype. Then, if the client decides to move forward, the company invests in bringing the product market through animal and human trials.

Dragon ID is internally funded through contracts with hospitals and doctors. The company has also won grant awards from MAGNET and the Innovation Fund.

The New Ventures Healthcare Challenge once again will kick off the Cleveland Clinic’s 2014 Medical Innovation Summit, introducing the world to healthcare information technology companies with new and creative concepts.
 
"We’re looking for anything creative, innovative or inspiring," says Gary Fingerhut, executive director of Cleveland Clinic Innovations (CCI). “We want anything that’s going to revolutionize the health of our patients.”
 
While the summit does not start until October 27, the deadline for the first round of the challenge -- a video submission -- is Friday, May 30. “This year is a much more structured approach, with three rounds,” says Fingerhut. “There is the new video round, which explains what’s unique, why the idea is a game changer and how big an impact it will have." The second round is a web conference presentation. A select group of candidates will then be asked to present at the summit to a panel of experts and venture capitalists."
 
The winning company will work with CCI and its advisory board on commercialization strategies. The team will also demonstrate its product to a select group of Cleveland Clinic caregivers.
 
“Last year, the competition added a lot of energy because we had these really bright entrepreneurs from 40 states and 20 countries,” says Fingerhut. “It’s an exciting way to kick things off.” Eleven teams ultimately presented their concepts to the board.
 
Last year’s winner presented a thermometer that connects to the cloud for predictive analysis of the flu across the country. CCI currently is assisting the team with commercialization end of the product.
 
Applicants must submit a You Tube link to MIS2014@ccf.org  by May 30 to be considered for the video round.
 

Rachel Kingsbury, a young, first-time entrepreneur who previously worked as a restaurant manager at Town Hall and Liquid Planet, has signed a lease to open The Grocery in a long-vacant building at 3815 Lorain Avenue. The 1,000-square-foot neighborhood market will offer everything from produce to meat to dairy, much of it sourced from local farmers.

"In addition to having thriving entertainment districts, other cities have essentials like grocery stores, bread shops and butchers," she says. "That's what spawned my desire to open a grocery store in Ohio City. This is something I felt was necessary for the development of Cleveland and the development of the neighborhood. I decided to focus more on organic-style products because people are becoming more conscious eaters. They're very aware of where their food comes from."

The owners are restoring the exterior through the City of Cleveland's Storefront Renovation Program. They will bring back the original transom windows, adding more natural light to the store, which has 12-foot ceilings on the main floor.

Kingsbury says she was attracted to the location because of other new businesses in the area, such as Jackflaps, which often has a line out the door during weekend brunch, she says, Platform Beer Company and Buck Buck Studio and Gallery.

She says that she wants her store to serve the entire community, and she's looking into accepting EBT and WIC. "This is the kind of place you go to shop every couple days and bump into your neighbor there. We want to be an integral part of building a very strong community."

In addition to local produce and pasture-raised meats, The Grocery will feature value-added products created by area food entrepreneurs. Kingsbury is partnering with the Economic and Community Development Institute (ECDI), a microlender with offices in the Midtown neighborhood, and Cleveland Culinary Launch to stock her shelves with products they're helping bring to market.

The Grocery will be open seven days a week: 7 a.m. to 7 p.m. on weekdays, 9 a.m. to 6 p.m. on Saturdays and noon to 6 p.m. on Sundays. Kingston is keeping the buildout simple, and has applied for permits and licenses through the City of Cleveland. She also is pursuing an equipment loan from ECDI. She plans to open in July.


Source: Rachel Kingsbury
Writer: Lee Chilcote

If you're considering a move to Cleveland, there might be no better means to examine the broad range of residential options than by hopping aboard a City Life tour hosted by Cleveland Neighborhood Progress. In a few short hours, participants enjoy an immersive dive into a number of Cleveland's most in-demand neighborhoods.
 

Austin McGuan, an attorney with Squire Sanders, first learned about the City of Cleveland's bike parking ordinance a few years ago. A regular bike commuter, McGuan began inquiring about his own landlord's bike parking facility and learned that it was not in compliance. So he worked with his firm, the landlord and the building management to reach a good solution.

Today, thanks to the efforts of McGuan and other members of the Squire Sanders bike committee, the firm has safe, covered bike parking at the front of the garage, offers employees memberships in the Bike Rack downtown, and sponsors regular bike commuting and recreational events. The firm recently received a silver-level bicycle friendly business designation -- the only company or organization in Northeast Ohio to receive this coveted award, and the fourth in Ohio.

"Before, we had a rim-bender bike rack that was tucked into a dark corner, always in a puddle," says McGuane. "If you want to encourage people to ride a bike to work, you have to provide them with a good and safe place to park their bike. That’s what we’ve done working with building management here."

McGuane says one of the most important aspects of fostering bike commuting is encouraging bike-friendly workplaces. "We wanted to knock down potential barriers that would prevent someone from biking to work," he says of his colleagues at Squire Sanders. "One of them, obviously, is having someplace to shower, clean up and change. We explored providing that within our own building, but instead we decided to do the next best thing, which was to sponsor the Bike Rack."

Jacob Van Sickle of Bike Cleveland says the number of bike commuters has been steadily rising in Cleveland and especially downtown in recent years. It's critical to offer a bike-friendly work environment in order to attract more commuters, he says. Although more is needed, the Bike Rack's growing membership, increasing number of parking lot owners in compliance with the city's ordinance, and newly installed bike racks downtown all are part of the amenity mix falling into place.